Sophocarpine
作者：齊岳
發布時間：2023-08-25
08:58:43
點擊數：
產品名稱：Sophocarpine
產品描述：
| 植物來源 | 天然產物 > 豆科 > 苦參屬 |
| 結構類型 | 天然產物 > 生物堿 |
| 產品描述 | Sophocarpine has anti-cancer, anti-inflammatory, anti-nociceptive, and antivirus activities, it can prevent implant loosening through inhibiting osteoclast formation and bone resorption, thus, it may be a novel therapeutic agent to prevent prosthesis loosening and for osteolytic diseases. Sophocarpine could attenuate ConA-induced liver injury, and the protective effect of Sophocarpine was associated with its inhibition effect of pro-inflammatory cytokines, chemokines, and the IFN-γ/STAT1 signaling pathway. |
| 體外活性 | Sophocarpine exerts anti-cachectic effects by inhibiting TNF-α and IL-6 production in both RAW264.7 cells and murine primary macrophages. [1] Sophocarpine also shows antivirus activity by inhibiting HHV-6 replication in Molt-3 cells. [2] In addition, Sophocarpine is a potent blocker of HERG K+ channels with an IC50 of about 200 mM. [3] |
| 體內活性 | Administration of 50 mg/kg/d sophocarpine for 5 days from the onset of cachexia does not inhibit the tumor growth but results in attenuation of cachexia symptoms in colon26 adenocarcinoma xenograft BALB/c mice. [1] LD50: Mice 63.94 mg/kg (i.v.) [4] |
| 分子量 | 246.35 |
| 分子式 | C15H22N2O |
| CAS No. | 6483-15-4 |
存儲
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
Ethanol: 49 mg/mL (198.9 mM)
H2O: 5 mg/mL(20.30 mM)
H2O: 49 mg/mL (198.9 mM)
DMSO: 49 mg/mL (198.9 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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