Toceranib
作者：齊岳
發布時間：2023-08-25
09:08:35
點擊數：
產品名稱：Toceranib
產品描述：
| 產品描述 | Toceranib phosphate is an orally active inhibitor of tyrosine kinase (RTK) receptor, and it potently inhibits PDGFR, VEGFR, and Kit(with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively), has antitumor and antiangiogenic activity. |
| 靶點活性 | PDGFRβ:5 nM (ki), Flk-1:6 nM (ki) |
| 體內活性 | Administration of toceranib significantly decreased the number and percentage of Treg in the peripheral blood of dogs with cancer. Dogs receiving toceranib and CYC demonstrated a significant increase in serum concentrations of IFN-γ, which was inversely correlated with Treg numbers after 6 weeks of combination treatment[1]. |
| 別名 | PHA 291639E, 托西尼布, SU11654 |
| 分子量 | 396.46 |
| 分子式 | C22H25FN4O2 |
| CAS No. | 356068-94-5 |
存儲
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 2.4 mg/mL (6.05 mM),Need ultrasonic
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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