Dapivirine
作者：齊岳
發布時間：2023-08-30
09:02:49
點擊數：
產品名稱：Dapivirine
產品描述：
| 產品描述 | Dapivirine is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor. |
| 靶點活性 | HIV reverse transcriptase:24 nM |
| 體內活性 | Dapivirine-containing gel at vaginal level inhibits cell-associated HIV infection in mice. [3] More placebo (7 of 12) than Dapivirine (3 of 24) gel users has positive vaginal swab results, with white blood cells being the most common finding. Dapivirine (0.05%) results in Cmax of 715 pg/mL, AUC of 15 ng×h/mL and T1/2 of 89.87 hours in plasma after 14 days post-dose. Mean Dapivirine (0.05%) concentrations in vaginal fluids collected at the introitus, mid vagina, and cervix are in the range of 62-265 μg/g on day 1. [4] |
| 別名 | TMC120, 達匹維林, R147681 |
| 分子量 | 329.4 |
| 分子式 | C20H19N5 |
| CAS No. | 244767-67-7 |
存儲
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
Ethanol: <1 mg/mL
DMSO: 32 mg/mL (97.1 mM)
H2O: <1 mg/mL
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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