CNX-774
作者：齊岳
發布時間：2023-08-23
09:17:11
點擊數：
產品名稱：CNX-774
產品描述：
| 產品描述 | CNX-774 is a highly specific, irreversible, and orally active BTK inhibitor (IC50<1 nM). |
| 靶點活性 | BTK:<1 nM |
| 體內活性 | 在細胞試驗中,CNX-774以BTK的ATP結合位點Cys-481殘基為靶點從而抑制其活性（IC50：1-10 nM）。 |
| 激酶實驗 | In vitro kinase assays: The p38α and p38β are assayed in 25 mM Tris-HCl, pH 7.5, containing 0.1 mM EGTA, with myelin basic protein (0.33 mg/mL) as substrate. Assays are performed either manually for 10 minutes at 30 °C in 50 μL incubations using [γ-33P]ATP, or with a Biomek 2000 Laboratory Automation Workstation in a 96-well format for 40 minutes at ambient temperature in 25 μL incubations using [γ-33P]ATP. The concentrations of ATP and magnesium acetate are 0.1 mM and 10 mM respectively. All assays are initiated with MgATP. Manual assays are terminated by spotting aliquots of incubation on to phosphocellulose paper, followed by immersion in 50 mM phosphoric acid. Robotic assays are terminated by the addition of 5 μL of 0.5 M phosphoric acid before spotting aliquots on to P30 filter mats. All papers are then washed four times in 50 mM phosphoric acid to remove ATP, once in acetone (manual incubations) or methanol (robotic incubations), and then dried and counted for radioactivity. |
| 別名 | CNX 774 |
| 分子量 | 499.506 |
| 分子式 | C26H22FN7O3 |
| CAS No. | 1202759-32-7 |
存儲
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
Ethanol: 2 mg/mL (4.0 mM)
H2O: <1 mg/mL
DMSO: 93 mg/mL (186.2 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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西安齊岳生物科技有限公司是集化學科研和定制與一體的高科技化學公司。業務范圍包括化學試劑和產品的研發、生產、銷售等。涉及產品為通用試劑的分銷、非通用試劑的定制與研發，涵蓋生物科技、化學品、中間體和化工材料等領域。
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