Puerarin 6''-O-Xyloside
作者：齊岳
發布時間：2023-08-29
13:40:51
點擊數：
產品名稱：Puerarin 6''-O-Xyloside
產品描述：
| 植物來源 | 天然產物 > 豆科 > 葛屬 |
| 結構類型 | 天然產物 > 類黃酮 |
| 產品描述 | Puerarin 6''-O-xyloside possesses significant anti-osteoporotic activity on ovariectomy mice, it has significant antitumour activities, the mechanisms are related to increased levels of caspase-3, caspase-7, caspase-9 and Bax, and reduced levels Bcl-2. |
| 體內活性 | The in vivo animal study showed that POS significantly inhibited tumour growth in A549 cells (p?<?0.01). The POS has significant antitumour activities. The mechanisms are related to increased levels of caspase-3, caspase-7, caspase-9 and Bax, and reduced levels Bcl-2[1]. |
| 動物實驗 | The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to determine the cytotoxicity of POS (at 10, 20 and 40?μM) in vitro, and xenograft nude mice were established to evaluate the antitumour effect of POS (at 40?mg/kg/d) in vivo by 15 days intraperitoneal injection (ip). To explore its mechanism of action, flow cytometry was performed to determine the pro-apoptotic effect of POS (at 10, 20 and 40?μM). Subsequently, the expression of caspase-3, caspase-7, caspase-9, Bcl-2 and Bax in A549 cells were determined[1]. |
| 分子量 | 548.497 |
| 分子式 | C26H28O13 |
| CAS No. | 114240-18-5 |
存儲
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 25 mg/mL (45.58 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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