Gliotoxin
作者：齊岳
發布時間：2023-08-30
09:00:20
點擊數：
產品名稱：Gliotoxin
產品描述：
| 結構類型 | 天然產物 > 其他 |
| 產品描述 | Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. Gliotoxin is a mycotoxin produced by several moulds such as Aspergillus fumigatus. Gliotoxin activates PKA and increases intracellular cAMP concentration and inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis. |
| 靶點活性 | Mycobacterium tuberculosis:<0.03 μM(MIC50) |
| 體外活性 | The structures of these compounds (1-12) were determined mainly by the extensive NMR, ESIMS spectra data and by comparison with previously described compounds. Besides, anti-tuberculosis, cytotoxic, antibacterial, COX-2 inhibitory and antiviral activities of these compounds were evaluated[1] |
| 分子量 | 326.39 |
| 分子式 | C13H14N2O4S2 |
| CAS No. | 67-99-2 |
存儲
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
Chloroform: 10 mg/mL
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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