Y15
作者：齊岳
發(fā)布時間：2023-08-24
09:17:26
點擊數：
產品名稱：Y15
產品描述：
| 產品描述 | Y15 is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth. |
| 體外活性 | Y15 inhibited viability in ?thyroid cancer cell lines in a dose-dependent manner[1]. |
| 細胞實驗 | Apoptosis assay was done with PE Annexin V Apoptosis Detection Kit (BD) to identify apoptotic nuclei.?One hundred millimeter plates were seeded with TPC1, K1, BCPAP and TT cells at a concentration of 1 × 10^6 cells in normal growth media.?After overnight incubation, plates were treated with one of several doses of Y15 or left untreated.?After another 24 h of incubation, cells were collected with trypsin, and following centrifugation, were washed with 1× PBS.?Again, cells were centrifuged, PBS was removed and cells were resuspended in binding buffer and filtered through BD mesh tubes.?Annexin V and 7-AAD were added to the solution, vortexed and incubated for 15 minutes in the dark.?Binding buffer was added and the cells were analyzed by flow cytometry within 1 hour. |
| 別名 | 1,2,4,5-苯四胺四鹽酸鹽, FAK inhibitor Y15, 1,2,4,5-Benzenetetramine tetrahydrochlor, FAK Inhibitor 14 |
| 分子量 | 284.01 |
| 分子式 | C6H14Cl4N4 |
| CAS No. | 4506-66-5 |
存儲
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
H2O: 59 mg/mL (207.74 mM),Need ultrasonic and warming
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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